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Tag: NASDAQ: APTX

  • Aptinyx Inc. (APTX) Witnesses Remarkable Recovery Amidst Challenges

    Aptinyx Inc. (NASDAQ: APTX), a clinical-stage biopharmaceutical company specializing in brain and nervous system disorder treatments, is experiencing an astonishing after-market price surge.

    Despite a challenging day, the stock is making an epic recovery, soaring by an impressive 21% after hours. This unexpected jump is capturing attention and raising speculation about the factors driving Aptinyx Inc.’s remarkable after-market performance.

    Not all Hope is Lost for Aptinyx

    Aptinyx Inc. (APTX) faced a sell-off during the day, amid dissolution scares, dropping from $0.10 to $0.06. However, after hours, the stock experienced a significant rebound as bullish investors drove it back up to nearly $0.08.

    While the future remains uncertain, there are possibilities of a business combination or exploring alternative options instead of dissolution. With available funds and multiple scenarios on the table, APTX’s situation continues to be dynamic, attracting attention from investors seeking potential opportunities.

    APTX Milestone Challenges

    Aptinyx, earlier this year, faced challenges in its milestone update. The Phase 2b clinical study of NYX-783 for post-traumatic stress disorder (PTSD) did not show enough improvement to continue the program.

    Aptinyx engaged Ladenburg Thalmann as an advisor for strategic alternatives and implemented workforce reduction to cut costs. Another study with NYX-458 for cognitive impairment associated with Parkinson’s disease did not demonstrate meaningful improvements.

    However, the company is still pursuing the development of NYX-783 as a treatment for opioid use disorder (OUD), with ongoing research collaboration and funding from the National Institutes of Health (NIH).

    Conclusion

    The surge in the price of APTX is nothing short of remarkable. While uncertainties loom, Aptinyx remains resilient, exploring potential business combinations and alternatives.

    Despite setbacks, the company continues its pursuit of developing NYX-783 for opioid use disorder, supported by research collaboration and funding from the National Institutes of Health (NIH). Investors are closely watching APTX for potential opportunities amidst its dynamic situation.

  • Aptinyx Inc. (APTX) stock rises in the pre-market trading. Here’s to know why?

    Aptinyx Inc. (APTX) stock surged by 7.33% at the last trading close while the APTX stock continued to show gains by 1.86% in the pre-market trading as well after APTX announced that it has recommenced the screening of patients in a Phase 2 study of NYX-458. Aptinyx is a clinical-stage biopharmaceutical company that develops and commercializes patented synthetic small molecules for the cure of brain and nervous system disorders.

    What is happening?

    Today on April 6, 2021, APTX stock has reported that patient screening for a Phase 2 trial of NYX-458 in patients with moderate cognitive impairment, mild dementia associated with Parkinson’s disease, and dementia with Lewy bodies has started again. The results of this study are expected to be released in the second half of 2022, according to the company.

    NYX-458 is a novel oral NMDA receptor modulator that is currently being studied in clinical trials for the cure of cognitive dysfunction in Parkinson’s disease and dementia with Lewy bodies. In a design that is closely comparable to Parkinson’s disease in humans, NYX-458 has been shown to reverse cognitive deficits in nonhuman primates.

    Outlook of Phase 2 study

    The Phase 2 study is a randomized, double-blind, parallel-design, placebo-controlled trial in about 100 patients with moderate cognitive impairment or mild dementia linked with Parkinson’s disease or prodromal or indicate dementia with Lewy bodies to assess the safety and possible cognitive benefits of NYX-458.

    Over the course of 12-week duration, the study aims to compare daily oral dosing of NYX-458 30 mg to placebo. NYX-458’s overall safety and efficacy in patients will be assessed, as well as the drug’s possible cognitive benefits across various neurocognitive endpoints based on the concentration, memory, and executive function.

    Furthermore,

    The CEO of Aptinyx Norbert Riedel said that they are hoping for positive results from the evaluation of NYX-458 in patients who are suffering from cognitive impairment. He also added that current treatments for these patients often fail to provide significant results, and new treatment approaches are desperately needed. They also assume that NYX-458’s mechanism is ideally suited to solve these patients’ cognitive deficits, and they look forward to building on the convincing preclinical evidence we’ve gathered so far with NYX-458.

  • Profitable Stocks to Trade Today for  Exponential Gains

    Profitable Stocks to Trade Today for  Exponential Gains

    Aptinyx Inc [NASDAQ: APTX]

    Clinical-stage biopharmaceutical company Aptinyx Inc., reported today of its positive results from the second phase of its novel NVDA receptor module, NYX-783 clinical trial.

    The study involved 153 patients suffering from post-traumatic-stress disorder (PTSD). In this study, NYX-783 showed statistically and clinically significant efficacy results of this treatment. Following these results, Aptinyx expects to kick-start a serious study in 2021. PTSD is one of the most difficult psychiatric conditions to treat due to multiple debilitating symptoms.

    Murray Stein, the Vice-Chair for Clinical Research in Psychiatry at the University of California San Diego says that it is encouraging to get such positive results and considering the short duration that NYX-783 takes to cure this disorder.

    Uxin Ltd [NASDAQ: UXIN]

    Uxin Limited, an international online Chinese company dealing with used cars recently announced that it has entered into two definitive agreements with two investors that will see the company raise US$25,000,000.

    In these agreements, Uxin plans to issue an aggregate of 84,692,839 Class A ordinary shares through private placements that will occur in October 2020. Additionally, Uxin also entered into a letter agreement with affiliates of TPG, 58.com and Warburg Pincus to alter the conversion of price of the convertible notes in an aggregate total of about US$230 million.

    Based on this letter in two years after the agreement, if the Company issues or sells any equity securities less than the conversion price, the strategic investors will have a right to convert all or a part of their convertible notes at a price that is equal to New Issue Price.

    Iterum Therapeutics Plc  [NASDAQ: ITRM]

    Iterum Therapeutics plc announced today that it will present its data at the Infectious Disease Society of America IDWeek that will take place virtually as from October 21, 2020.

    The data presentations will include results for SURE-2, that will show the effects in complicated urinary tract infections (cUTI) and oral abstract presentation that are results from SURE-1 in uncomplicated urinary tract infections..

    This data shows that oral sulopenem was statistically stronger than oral ciprofloxacin to treat patients with uncomplicated urinary tract infections. Iterum Therapeutics is a clinical-stage pharmaceutical institution that is focussed on developing oral and IV antibiotics for the treatment and management of infections caused by drug resistant pathogens in both hospital and home settings.